Santa Margarita, California

Santa Margarita is a census-designated place located in San Luis Obispo County, California. It was founded in 1889 near Cuesta Peak and San Luis Obispo along State Route 58. The town’s name comes from the Mexican Alta California land grant. It is home to the Santa Margarita de Cortona Asistencia. The population was 1,259 at the 2010 census.